Endometrial Receptivity Array | Dr Rama Sofat Hospital

What is the endometrium?

Endometrium is a tissue lining the interior of the uterus where the embryo implants and resides during pregnancy as explained by Dr Rama Sofat.

Each month the endometrium prepares for the arrival of an embryo. When this does not occur, menstruation begins.

What is the endometrium?

Endometrium is a tissue lining the interior of the uterus where the embryo implants and resides during pregnancy.

Each month the endometrium prepares for the arrival of an embryo. When this does not occur, menstruation begins.

What is the window of implantation (WOI)?

The period of receptivity, usually between days 19-21 of the menstrual cycle, is called the window of implantation.

Benefits of Endometrial Receptivity Array
When performing the embryo transfer in a personalized way, the chances of getting pregnant are increased after the assisted reproduction treatment.

The ERA test resulted in a 73% pregnancy rate in patients with implantation failure.

Using a small sample of endometrial tissue the ERA test establishes the best day for transferring the embryo.


Reproductive Genetics
It is estimated that genetics contribute up to 10 percent of infertility issues or recurrent pregnancy losses in couples. The risk of finding chromosomal abnormalities grows as the age of the mother increases. 

Most embryos with an incorrect number of chromosomes fail to implant or miscarry during the first trimester of pregnancy. Genetic testing protocols have the potential to help many of those couples in their quest to have a family. Our comprehensive list of genetic testing services can greatly increase your chances of becoming a mother as explained by Dr Rama Sofat.

Pre-implantation Genetic Screening (PGS)

The Concept
PGS is a last generation genetic test that allows us to screen for chromosomal abnormalities on embryos during an IVF cycle. The procedure requires to make a small biopsy on the embryos on which the analysis is performed as explained by Dr Rama Sofat.
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 PGS analyse all 24 chromosome types using array Comparative Genomic Hybridisation (aCGH), in order to detect aneuploidies (alterations in the number of chromosomes) and select chromosomally normal embryos for transfer which are the most likely to develop to term and to be born as a healthy baby. The most common syndromes caused by chromosome aneuploidies are Down syndrome, Edwards syndrome and Patau syndrome.

Who is this for
Most of spontaneous miscarriages and some birth defects are caused by chromosomal abnormalities and the risks of having a child with a chromosome abnormality increases with maternal age. For this reason, PGS is especially recommended for:

i. Women over 35 years of age

ii. Couples who have experienced several spontaneous miscarriages of unknown cause

iii. Couples with several cycles of IVF that have not achieved pregnancy

iv. Men with low sperm concentration

v. Couples with a previous pregnancy with chromosomal abnormality

Pre-implantation Genetic Diagnosis (PGD)

The Concept
While PGD also analyzes a small piece of the embryos during an IVF cycle to detect genetic alterations, it is focussed on single gene diseases or mutations. Common examples of monogenic disorders are cystic fibrosis, fragile X syndrome, spinal muscular dystrophies (SMA), Duchenne muscular dystrophy (DMD), Huntington disease. PGD helps couples who have an increased risk for a genetic disease to conceive a healthy pregnancy explaination by Dr Rama Sofat.

Who is this for
Fertile couples who have a known history of a genetic condition in their families.
Any condition for which the couple’s offspring are at risk.
Endometrial Receptivity Array [ERA ]

Treatment profile
The Concept
ERA is a personalized genetic test to diagnose the state of endometrial receptivity in the window of implantation. ERA determines the exact time period during which an embryo needs to be transferred into the woman’s uterus to achieve a successful pregnancy.